en گروه بایومواد Biomaterials Research Paper Research Paper <span style="font-size:11pt"><span style="line-height:200%"><span style="font-family:Calibri,sans-serif"><span new="" roman="" style="font-family:" times="">Amorphous calcium phosphate (ACP) which is a transient phase in natural bio-mineralization process has recently gained the spotlight. This study aimed to assess the effect of incorporation of nano-ACP (NACP) in a dental adhesive with/without surface treatment with silane coupling agent on bond strength.<b> </b>NACP<b> </b>was synthesized by the wet chemical precipitation technique. To characterize the structure of NACP, X-ray diffraction, scanning electron microscopy and energy dispersive X-ray spectroscopy were used. Forty molars were randomized into 4 groups of 10. The teeth were restored with composite resin and the bonding agent (one of the four groups). Adper Single Bond 2 was used as the control group. In 4wt% NACP group, NACP fillers were added to the bonding agent. In 0.4wt% and 4wt% SNACP groups, silanized NACP fillers were added to the bonding agent. Finally, the mode of failure of specimens was determined. Data were analyzed <span style="background-color:#ffffff;">by </span><span style="background:aqua"><span style="background-color:#ffffff;">one-way ANOVA and</span></span></span><span style="background-color:#ffffff;"> </span><span style="background:aqua"><span new="" roman="" style="font-family:" times=""><span style="background-color:#ffffff;">Tukey&#39;s post-hoc tests.</span></span></span><span new="" roman="" style="font-family:" times=""><span style="background-color:#ffffff;"> P<0.05 was considered statistically significant. Addition of 4wt% non-silanized NACP decreased the bond strength compared with the control group (P</span><0.05). The bond strength of the groups with silanized fillers was not significantly different from that of the control group. Addition of silanized NACP to dental adhesive had no significant adverse effect on bond strength, which is a promising finding to pave the way for the synthesis of bonding agents containing bioactive fillers. </span></span></span></span> Amorphous Calcium Phosphate,Silane,Bond Strength 1 10 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-4859-2&slc_lang=en&sid=1 Ali Hasanzade Salmasi Aliiiiiiiihz@gmail.com 1800319475328460017331 1800319475328460017331 No Postgraduate Student, Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mahban Zarei m.zareiii1995@gmail.com 1800319475328460017332 1800319475328460017332 No DDS Candidate, University of Pacific, Arthur Dugoni School of Dentistry, San Francisco, USA. Shadab Safarzadeh Khosroshahi shadab.kh@gmail.com 1800319475328460017333 1800319475328460017333 Yes Department of Operative Dentistry, Dental Material Research Center, Islamic Azad University of Medical Science, Tehran, Iran. Soolmaz Heidari Heidari.Soolmaz@gmail.com 1800319475328460017334 1800319475328460017334 No Department of Operative Dentistry, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Farhood Najafi fnajafi@icrc.ac.ir 1800319475328460017335 1800319475328460017335 No Department of Resin and Additives, Institute for Color Science and Technology, P.O. Box:16765-564, Tehran, Iran. Mojtaba Ghomayshi mojtaba2034ghomayshi@gmail.com 1800319475328460017336 1800319475328460017336 No Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran. Katayoun Lesani Katylesani.omfr@gmail.com 1800319475328460017337 1800319475328460017337 No Postgraduate Student, Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.