en Research Paper Research Paper <div style="text-align: justify;"><em>Our study is to highlight the effect of the acid-base character and the redox potential of two clays, synthetic anionic Layered Double Hydroxides Zn₃Al-CO₃(LDH) clay, and natural commercial cationic clay &quot;Ghassoul&quot; on their antioxidant and antibacterial activities. The antibacterial effect was tested on two Gram-positive bacteria: Staphylococcus aureus and Enterococcus faecalis. Then it was tested on a Gram-negative bacterium: Escherichia coli. The determination of the minimum inhibitory concentration of the two materials was carried out using the microplatemicrotitration technique. The antioxidant activities of clays are assessed by the methods 2.2-diphenyl-1-picrylhydrazyl and the reducing power of iron (Fe³⁺).</em> The redox potential (Eh) was measured and the redox strength (rH2) was evaluated. The results showed that these materials have an antibacterial effect on the three bacteria tested, the measured zero charge point of Ghassoul (pH_zpc =8.75) more basic than that of double layer hydroxide (pH_zpc =7.5), redox potential of LDH (-27mV) was higher than that of Gh (- 103mV), and the rH2 of Gh (14.04) was higher compared to anionic clay (13.33).<br> <strong><em>Keywords: </em></strong><em>LDHs, Ghassoul, Redox Potential, Zero point of Charge, Antibacterial.</em></div> LDHs,Ghassoul,Redox Potential,Zero point of Charge,Antibacterial 1 13 http://ijmse.iust.ac.ir/browse.php?a_code=A-10-3619-5&slc_lang=en&sid=1 Jaouad Zerhouni boumnihi_jaouad@hotmail.com 1800319475328460014773 1800319475328460014773 Yes Microbiology and health team: laboratory of Chemistry Biology applies to the environment, Faculty of Sciences, Moulay Ismail, Meknes University, Morocco Fouzia Rhazi Filali 1800319475328460014774 1800319475328460014774 No 1Microbiology and health team: laboratory of Chemistry Biology applies to the environment, Faculty of Sciences, Moulay Ismail, Meknes University, Morocco Mohammed Naciri Bennani 1800319475328460014775 1800319475328460014775 No 2Materials and applied Catalysis team: laboratory of Chemistry Biology applied to the environment, Faculty of Sciences, Meknes, Morocco Omar Qabaqous 1800319475328460014776 1800319475328460014776 No 2Materials and applied Catalysis team: laboratory of Chemistry Biology applied to the environment, Faculty of Sciences, Meknes, Morocco Aziz Bouymajane 1800319475328460014777 1800319475328460014777 No 1Microbiology and health team: laboratory of Chemistry Biology applies to the environment, Faculty of Sciences, Moulay Ismail, Meknes University, Morocco Jamal Houssaini 1800319475328460014778 1800319475328460014778 No 2Materials and applied Catalysis team: laboratory of Chemistry Biology applied to the environment, Faculty of Sciences, Meknes, Morocco Safae Allaoui 1800319475328460014779 1800319475328460014779 No 2Materials and applied Catalysis team: laboratory of Chemistry Biology applied to the environment, Faculty of Sciences, Meknes, Morocco Faouzia Benhallam 1800319475328460014780 1800319475328460014780 No 1Microbiology and health team: laboratory of Chemistry Biology applies to the environment, Faculty of Sciences, Moulay Ismail, Meknes University, Morocco