Yazdani N, Javadpour J, Eftekhari Yekta B, Hamrang M. Hydrothermal Synthesis of Cobalt- Doped Hydroxyapatite Nanoparticles: Structure, Magnetic Behaviour, Bioactivity and Antibacterial Activity. IJMSE 2019; 16 (1) :39-48
URL:
http://ijmse.iust.ac.ir/article-1-1067-en.html
Abstract: (19900 Views)
This study focuses on the physical, magnetic, biological and antibacterial behaviour of cobalt-doped HAp powder samples. Pure and Cobalt- doped HAp nanoparticles were synthesized by hydrothermal method. Calcium nitrate, di- ammonium hydrogen phosphate and cobalt nitrate were used as precursor materials. The synthesized powders were characterized using x-ray diffraction pattern (XRD), fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), vibrating sample magnetometer (VSM), Raman spectroscopy as well as MTT assay and cell adhesion test. Disc diffusion method was used to investigate antibacterial activity of the samples. The results confirmed the substitution of Ca by Co ions in the HAp lattice. In addition, this substitution induced size reduction and morphology change in HAp particles. All cobalt substituted HAp powder samples displayed paramagnetic properties, as opposed to the diamagnetic behaviour observed in the pure HAp samples. In addition, these nanoparticles exhibited cell adhesion, biocompatibility and antibacterial activity against S.aureus bacteria.
This study focuses on the physical, magnetic, biological and antibacterial behaviour of cobalt-doped HAp powder samples. Pure and Cobalt- doped HAp nanoparticles were synthesized by hydrothermal method. Calcium nitrate, di- ammonium hydrogen phosphate and cobalt nitrate were used as precursor materials. The synthesized powders were characterized using x-ray diffraction pattern (XRD), fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), vibrating sample magnetometer (VSM), Raman spectroscopy as well as MTT assay and cell adhesion test. Disc diffusion method was used to investigate antibacterial activity of the samples. The results confirmed the substitution of Ca by Co ions in the HAp lattice. In addition, this substitution induced size reduction and morphology change in HAp particles. All cobalt substituted HAp powder samples displayed paramagnetic properties, as opposed to the diamagnetic behaviour observed in the pure HAp samples. In addition, these nanoparticles exhibited cell adhesion, biocompatibility and antibacterial activity against S.aureus bacteria.
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- Formation of a single phase cobalt- doped HAp
- Paramagnetic properties of Co- substituted HAp lattice, as opposed to diamagnetic behavior in pure HAp
- No toxicity and good adherence of MG63 cells onto the Co- substituted substrates
- Nearly twice as much alkaline phosphatase activity in the presence of Co ions.
- An increase in antibacterial activity in Co- doped particles against S. aureus bacteria
Type of Study:
Research Paper |
Subject:
Ceramics